Three siblings travelling home from a NSW fair have been killed in a "split second" in a horrific crash between two trucks and a car in northern NSW.

The head-on collision occurred on the Newell Highway, about 30 kilometres south of the NSW town of Boggabilla, near the Queensland border, about 6am on Monday.

Jack Pink, 19, and his sisters Marina, 17, and Destiny, 15, were killed instantly while travelling in two of the three vehicles involved in the collision.

The siblings are part of a family that works on the travelling show circuit, Showmens Guild of Australasia vice-president Broderick Pavier said.

It is believed they were travelling home to Brisbane after attending a show in Dubbo.

Their grandfather is outgoing Guild president and legendary third-generation showman George Pink, Mr Pavier confirmed.

Jack Pink was driving a pantech truck and towing a trailer. His sisters were in a car, police said.

It is understood the pantech truck and the car collided head-on with a second truck - a fuel tanker - that then caught alight.

NSW Police said an investigation had been launched to determine how the fuel tanker, the pantech truck towing a trailer, and the car collided.

A GoFundMe page set up to support parents Jaze and Glenn and surviving siblings Coral, Jeanna, George and Patrick said the family was "amazing".

"What [Jaze and Glenn Pink] do is everything for the kids. To lose 1 would be crazy. [The fact they] lost 3 in 1 split second is just out of this world," the page said.

"They are great people and their sacrificial love for their kids knows no bounds. This is a crushing blow to this tight knit family."

The page said Tuesday would have been Marina's 18th birthday.

Mr Pavier said the show community was small and everyone was in deep shock.

"They were young kids with their whole lives in front of them," he said. "As you can imagine, we're all pretty close. This will have a huge impact across our community."

Superintendent Glen Maule, from the Queensland Ambulance Service, said debris from the crash was spread over a large section of the highway.

Paramedics took the driver of the fuel tanker to Goondiwindi Hospital with back pain and cuts to his face, Superintendent Maule said.

The Royal Automobile Club of Queensland (RACQ) LifeFlight helicopter service said the tanker driver was ejected from his truck during the crash and was later airlifted to hospital with suspected head, limb and internal injuries.

Police have set up a crime scene at the crash site and will prepare a report for the coroner.

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