Emergency services have been called to the Newell Highway north of Dubbo amid reports of a crash involving numerous vehicles.
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It is believed a number of people are trapped following the incident which occurred about 12.30pm on Tuesday.
About 20 emergency service vehicles are on the scene.
Live Traffic NSW reports the crash involved four vehicles – two cars and two trucks – with traffic affected in both directions.
The crash investigation unit and other emergency services are on the scene.
Motorists are urged to exercise caution.
More to come.